Cutting patches
- 02 Dec 2023
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Cutting patches
- Updated on 02 Dec 2023
- 1 Minute to read
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- Matrix patches can be cut to make small dose adjustments.
- Adjusting patches in this way it is off-license and is presently not supported by manufacturers.
- However, cutting patches is possible because for each formula of matrix patch, the hormone release rate is proportional to the surface area.
- For example, cutting an Estradot 75mcg patch in half will provide two Estradot 37.5mcg patches. Alternatively, cutting a small corner off an Evorel Conti patch will reduce the dose of both estradiol and norethisterone equally.
In the UK all available patches containing 17-beta estradiol are matrix patches.
| Matrix patches |
|---|
| Estradot |
| Evorel |
| Estraderm MX |
| FemSeven |
| Progynova TS |
| Evorel Sequi and Evorel Conti |
| FemSeven Sequi and FemSeven Conti |
References and Further Information:
- Ankaraberg-Lindgren C, Gawlik A, Kristrim B. Estradiol matrix patches for pubertal induction: stability of cut pieces at different temperatures. Endocr Connect. 2019.
- Castelo-Branco C and Soveral I. Clinical efficacy of estradiol transdermal system in the treatment of hot flashes in postmenopausal women. Research and reports in transdermal drug delivery. 2014.
- Laing A and Hillard T. Oestrogen based therapies for menopausal symptoms. Best Practice and Research Clinical Endocrinology & Metabolism. June 2023.
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