Sequential combined
  • 11 Dec 2023
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Sequential combined

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Article summary

PATCHES

BrandOestrogenProgestogenFormulationDosingBleedVegan suitable
Evorel SequiEstradiol (50mcg)Norethisterone (170mcg)PatchesApply patch to skin below waist and change every 3–4 days using a different siteMonthlyYes
FemSeven SequiEstradiol (50mcg)Levonorgestrel (10mcg)PatchesApply patch to skin below waist and change every 7 days using a different site. This patch is long term out of stock, but resupplies are expected in 2024MonthlyYes

TABLETS

BrandOestrogenProgestogenFormulationDosingBleedVegan suitable
Elleste Duet Estradiol (1,2mg)Norethisterone (1mg)TabletsTake one tablet daily without a breakMonthlyNo
Femoston 1/10Estradiol (1mg)Dydrogesterone (10mg)TabletsTake one tablet daily without a breakMonthlyNo
Femoston 2/10Estradiol (2mg)Dydrogesterone (10mg)TabletsTake one tablet daily without a break MonthlyNo
NovofemEstradiol (1,2mg)Norethisterone (1mg)TabletsTake one tablet daily without a breakMonthlyNo
TridestraEstradiol (2mg)Medroxyprogesterone Acetate (20mg)TabletsTake one white tablet daily for 70 days, then one blue tablet for 14 days, then one yellow tablet for 7 daysQuarterlyNo
TrisequensEstradiol (2,2,1mg)Norethisterone (1mg)TabletsTake one tablet daily without a breakMonthlyNo
Note:
  • If menstruation is regular, women should be advised to check the pack instructions about how to start the preparation in line with their cycle. 
  • If menstruation is irregular, HRT can be started at any time and the patient advised to keep a bleed diary.
  • For sequential combined oral tablets the pills in each pack differ in colour and must be taken daily in sequence as stated in the patient information leaflet.

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