DMPA injectable
  • 30 Nov 2023
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DMPA injectable

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Article summary

  • The progestogen only injectable (DMPA) is highly likely to be effective for endometrial protection with oestrogen as part of HRT; however, it cannot be recommended for this use due to a lack of data.
  • DMPA injections are safe to use alongside HRT.

  • Examples include Depo Provera (lasts 13 weeks), Sayana Press (13 weeks) and Noristerat (8 weeks).
  • Most women will be amenorrheic with their use.

  • Women should be informed that DMPA injections are associated with a small reduction in bone mineral density, but this usually recovers after discontinuation.
  • These are considered high dose progestogens. Other lower dose options might be preferable in menopausal women.
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