Chronic disease prevention

HRT should not be recommended for the sole purpose of disease prevention (in women without POI) who are experiencing the menopause. This is not recommended in national or international guidelines.

NICE says:

• The indication for HRT prescribing in the UK is for menopausal symptoms.
• Do not offer combined or oestrogen only HRT for primary or secondary prevention of cardiovascular disease. For ways to prevent cardiovascular disease, refer to NICE guidance on cardiovascular disease risk assessment and reduction.
• Do not offer HRT for the purpose of dementia prevention. There may be a misconception that HRT protects against dementia. The evidence does not support this, and HRT should not be prescribed to prevent dementia. For dementia prevention, see NICE guidance.
• Overall, taking either oestrogen only or combined HRT is unlikely to increase or decrease life expectancy.