Contraindications
  • 01 Dec 2023
  • 1 Minute to read
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Contraindications

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Article summary

Do not prescribe HRT in women with:

  • Current, past or suspected breast cancer.
  • Current, past or suspected ductal carcinoma in situ (DCIS).
  • Current, past or suspected oestrogen dependent cancer.
  • Undiagnosed vaginal bleeding.
  • Untreated endometrial hyperplasia.
  • Active or recent arterial thromboembolic disease.
  • Active liver disease with abnormal liver function tests.
  • Pregnancy.

Prescribe HRT with caution in women with:

  • Women at increased risk of breast cancer (seek guidance from menopause specialist or breast team).
  • Thrombophilia disorder or past history of VTE (seek guidance from menopause specialist or haematologist).
  • Factors predisposing to VTE (seek guidance from menopause specialist or haematologist).
  • Previous thrombotic stroke or MI (seek guidance from menopause specialist).
  • History of endometrial hyperplasia.
  • Epilespy who use Lamotrigine.
  • Porphyria cutanea tarda.
  • Meningioma.
  • Macroprolactinoma.
  • Nut or soya allergy (contained in some HRT types).
  • Veganism (gelatin and animal tallow is found in some HRT types).
  • Lactose intolerance (most oral tablets contain lactose).
Note:

The decision to start HRT in the setting of a known caution or contraindication can sometimes be made after a detailed risk benefit discussion with a specialist.

References and Further Information:

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